Beckman.com is conducting maintenance Saturday, September 19th and Sunday, September 20th. Parts of the site may have limited accessibility throughout the weekend. During this time, orders can still be placed by calling Client Services. We look forward to providing an improved customer experience. Beckman.com will return Monday, September 21st.
The CD62L antigen, also called LECAM-1, L-selectin or leucocyte adhesion molecule 1 [LAM-1], is a 75 kDa molecule, member of the selectin family. As other selectins (CD62E, CD62P), CD62L is a membrane-anchored Ca2+-dependent C-type lectin that binds to cell-surface carbohydrate ligands. CD62L acts as the peripheral lymph node homing receptor. It is also involved in lymphocyte binding to High Endothelial Venules (HEV) and in lymphocyte rolling on activated endothelium. CD62L is expressed by B and T lymphocytes, monocytes, neutrophils, eosinophils, and approximately half of the peripheral NK lymphocytes. It is also expressed by some spleen and bone marrow lymphocytes, as well as by some thymocytes and bone marrow myeloid cells. The expression level of CD62L on lymphocytes may be subject to control mechanisms such as downregulation and/or upregulation. On neutrophils, monocytes and their bone marrow precursors, CD62L is also downregulated by stimulation with granulocyte-macrophage colony stimulating factor (GM-CSF).
Isotype: IgG1 Mouse
In contrast to other antibodies recognizing this molecule, DREG56 is particularly effective in blocking CD62L mediated lymphocyte binding to lymph node HEV. DREG56 (ref.33) was used as a CD62L reference monoclonal antibody during the HLDA 6.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
There are currently no Technical Documents associated with this page or product. Please try our Technical Documents search
Related Products or Parts
Oops. The page you wanted could not be found, so we brought you to something similar. If you still can't find what you want, try searching our site instead.