Beckman.com is conducting maintenance Saturday, September 19th and Sunday, September 20th. Parts of the site may have limited accessibility throughout the weekend. During this time, orders can still be placed by calling Client Services. We look forward to providing an improved customer experience. Beckman.com will return Monday, September 21st.
How can small molecule drugs help boost the immune system?
Small molecule drugs target immune cell protein-protein interactions to modulate their function and counteract pathological mechanisms. Small molecule drug-based preclinical and clinical studies are an active area of research in cancer immunotherapy. This includes inhibitors for the CBP/EP300 bromodomain, the deubiquitylase USP7, as well as the T-cell response regulating proteins IDO1 and TDO.1
1. Y. Zheng, et al., "Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors," ACS Nano 11(3):3089-3100, 2017.
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